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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM4 All Species: 22.42
Human Site: T53 Identified Species: 35.24
UniProt: P33991 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33991 NP_005905.2 863 96558 T53 G E L Q P M P T S P G V D L Q
Chimpanzee Pan troglodytes XP_528129 863 96543 T53 G E L Q P M P T S P G V D L Q
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535063 929 104136 T119 G E L Q P M P T S P G A D L H
Cat Felis silvestris
Mouse Mus musculus P49717 862 96718 S53 E L L P M P T S P G A D L Q S
Rat Rattus norvegicus NP_387500 862 96552 S53 E L L P M P T S P G A D L Q S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515513 863 97108 T53 G D L Q P M P T S P G A D M Q
Chicken Gallus gallus XP_424376 859 96866 P53 L Q P L P T S P P A E Q S P R
Frog Xenopus laevis P30664 863 97105 T53 G E L L P M P T S P S G D V Q
Zebra Danio Brachydanio rerio NP_944595 750 84021
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 S55 N I S L P P T S P G N I S L P
Honey Bee Apis mellifera XP_624670 636 71159
Nematode Worm Caenorhab. elegans Q21902 759 84917 F16 I Y Y Q E R F F A N D G V P D
Sea Urchin Strong. purpuratus XP_801985 910 101460 S95 G E L P L M P S S P A S G E P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315
Baker's Yeast Sacchar. cerevisiae P30665 933 104985 S104 S A S A S G R S R Y H S D L R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.6 N.A. 94.9 95.1 N.A. 92.4 86.3 85.7 71.3 N.A. 60.1 42.1 28.1 63.3
Protein Similarity: 100 100 N.A. 90 N.A. 97 97.3 N.A. 96.1 93.1 92.9 78.7 N.A. 77.3 54.3 46.9 76.3
P-Site Identity: 100 100 N.A. 86.6 N.A. 6.6 6.6 N.A. 80 6.6 73.3 0 N.A. 13.3 0 6.6 46.6
P-Site Similarity: 100 100 N.A. 86.6 N.A. 13.3 13.3 N.A. 93.3 20 80 0 N.A. 26.6 0 13.3 53.3
Percent
Protein Identity: N.A. N.A. N.A. 28.9 42.6 N.A.
Protein Similarity: N.A. N.A. N.A. 46.5 62.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 0 0 0 0 7 7 20 14 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 0 7 14 40 0 7 % D
% Glu: 14 34 0 0 7 0 0 0 0 0 7 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % F
% Gly: 40 0 0 0 0 7 0 0 0 20 27 14 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % H
% Ile: 7 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 7 14 54 20 7 0 0 0 0 0 0 0 14 34 0 % L
% Met: 0 0 0 0 14 40 0 0 0 0 0 0 0 7 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 7 7 0 0 0 0 % N
% Pro: 0 0 7 20 47 20 40 7 27 40 0 0 0 14 14 % P
% Gln: 0 7 0 34 0 0 0 0 0 0 0 7 0 14 27 % Q
% Arg: 0 0 0 0 0 7 7 0 7 0 0 0 0 0 14 % R
% Ser: 7 0 14 0 7 0 7 34 40 0 7 14 14 0 14 % S
% Thr: 0 0 0 0 0 7 20 34 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 14 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 7 0 0 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _